Alzheimer’s Drug Shows Promise in Early Results of Study

Alzheimer’s Drug Shows Promise in Early Results of Study
Alzheimer’s Drug Shows Promise in Early Results of Study

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Shares of Biogen and other drugmakers researching Alzheimer’s disease soared early Wednesday after Japan’s Eisai Co. said its potential treatment appeared to slow the fatal disease’s progress in a late-stage study.

Eisai announced results late Tuesday from a global study of nearly 1,800 people with early-stage Alzheimer’s.

The drugmaker said early results showed that its treatment, lecanemab, reduced patient clinical decline by 27% when compared to a placebo or fake drug after 18 months of the infused treatment. Patients were monitored using a scale that measures how they do in areas like memory, judgement, problem solving and personal care.

Eisai Co. Ltd. said it would discuss full results from the research at a conference in late November. It also plans to publish its findings in a peer-reviewed medical journal.

The company is already seeking an accelerated approval from the U.S. Food and Drug Administration, and the agency is expected to decide by early next year. Eisai and Biogen will co-promote the drug.

The initial results appear to be “quite robust” and will likely support regulatory approval, Mizuho Securities analyst Graig Suvannavejh said in a research note.

A statement from the Alzheimer’s Association called the findings the most encouraging to date for potential treatments of the underlying disease causes.

Alzheimer’s is a progressive neurological disease with no known cure. Long-standing treatments on the market just manage symptoms, and researchers don’t fully understand what causes the disease.

Last year, Biogen’s Aduhelm became the first new Alzheimer’s drug introduced in nearly two decades. But it has largely flopped after debuting with a price tag of $56,000 annually, which Biogen later slashed.

Doctors have been hesitant to prescribe it, given weak evidence that the drug slows the progression of Alzheimer’s. Insurers have blocked or restricted coverage over the drug’s high price tag and uncertain benefit.

Like Aduhelm, lecanemab, which Eisai developed and ran through clinical trials, seeks to remove a protein called beta-amyloid from the brain.

But Eisai executives say lecanemab focuses more on floating clumps of the protein before it forms a plaque, which is what Aduhelm targets.

Eli Lilly and Co. also is developing a potential treatment, donanemab, that helps clear the protein.

Shares of Cambridge, Massachusetts-based Biogen Inc. jumped more than 50% in premarket trading Wednesday morning to top $300. The stock had largely tumbled since Aduhelm’s debut last year.

Shares of Indianapolis-based Eli Lilly and Co. were up 8%.

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The Pandemic Changed Paid Sick Leave, But Not For Everyone

The Pandemic Changed Paid Sick Leave, But Not For Everyone
The Pandemic Changed Paid Sick Leave, But Not For Everyone

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Starting next week, Starbucks workers will no longer have access to expanded paid sick leave that the company rolled out for COVID-19 illness, isolation, and vaccination. Going forward, employees will have to use whatever accrued sick time and vacation time they have to cover missed days should they fall sick with the virus—unless the state or city in which they work requires COVID-19 pay.

The coffee chain may be the latest large U.S. company to scrap its more generous sick-leave policies, but it’s hardly the first. When the U.S. Centers for Disease Control and Prevention (CDC) revised its quarantine and isolation guidance from 10 to five days late last year, for example, several major employers including Walmart and Amazon pulled back the amount of paid time off employees could take for COVID-19-related absences.

At the same time, however, state and local governments across the U.S. are enacting laws to ensure that companies operating in their jurisdictions provide workers with access to a minimum amount of paid sick leave. The question now is whether sick leave will become more widespread in a post-pandemic era, or largely revert back to pre-pandemic norms.

Americans’ spotty access to paid sick leave

When the pandemic hit the world in early 2020, the U.S. was the only one among 22 highly economically developed countries without guaranteed paid sick time, according to the Center for Economic and Policy Research. More than two years later, it still is. On Sept. 22, the Bureau of Labor Statistics released its annual paid leave benefits report that showed that 77% of private industry workers received paid sick leave in March 2022. That number has barely budged since the start of the pandemic, when 75% had paid sick leave.

Coverage is also uneven across the U.S. worker population. Large companies are more likely to provide some form of sick leave than smaller firms, as the below chart shows. Even more polarizing is worker salary: 94% of the highest earners have sick leave, compared with just 55% of the lowest earners. Such a disparity is especially sobering considering that lower-income essential workers, such as daycare providers and food-service employees, have little choice but to report to work in person, while higher-income desk workers can often perform their jobs at home.

One August analysis from researchers at the Urban Institute, a left-leaning think tank, and Boston University found that worker absences increased 50% in the first two years of the pandemic compared with the prior two years, with the biggest jumps among non-white and lower income workers. The data underscore the fact that disadvantaged populations are more likely to experience work absences due to personal or family illness, in part because their jobs have less flexibility.

At the same time, workers in these demographics are overall less likely to have paid sick leave benefits when they can’t report to work. The Urban Institute report found that while the unpaid absence rate increased by about 60% overall, it rose 74% for Black workers, and 83% for workers in households earning $25,000 to $50,000.

These findings are significant because the pandemic did spur governments and employers to offer more generous leave—but those efforts don’t cover all Americans, and the most vulnerable were left behind. In March 2020, the federal government offered paid leave for the first time under the Families First Coronavirus Response Act, giving two weeks to workers who were sick or were caring for a sick family member. The provision was narrow, as it excluded firms with 500 or more employees and allowed small employers to receive an exemption. What’s more, it was temporary, expiring about nine months after it was enacted.

Some states and smaller jurisdictions established or expanded paid leave laws during the pandemic, providing Americans with scattershot protections depending on where they work. Currently, 16 states have paid-leave laws, up from 10 prior to 2020, according to a September summary of laws compiled by Stateline, a nonpartisan news service funded by The Pew Charitable Trusts that tracks state policies, and A Better Balance, an organization that advocates for enhanced work-family policies. But at the same time, at least 17 states, most of which have no paid leave policies of their own, explicitly prohibit cities and counties from passing paid leave laws at the local level.

“Our approach in the U.S. has set us up for an economic failure and a public-health disaster,” says Chantel Boyens, a policy associate at the Urban Institute who co-authored the paper. “We had a lot of federal, state, and local actions—even private employer actions—in response to the pandemic to provide people with paid leave, but at the topline level, our data show that many workers were still not covered in a way that allowed them to take paid time off when they were sick. It’s a missed opportunity.”

Did the pandemic catalyze lasting change?

Still, Boyens is optimistic that sick-leave protections are moving in the right direction, and that the more state and local governments get on board, the more likely the federal government will take action. But it could still take a long time. President Biden’s Build Back Better proposal, which failed to gain enough support in the Senate to pass, had a number of social safety net provisions, including an original request for 12 weeks of paid family and medical leave, which was negotiated down to four weeks before the bill died.

Some experts who track benefits trends at the company level say that the available government data do not fully capture the nuances of paid-leave trends, and that many employers are improving leave benefits even as they roll back ones specific to COVID-19. Rich Fuerstenberg, a senior partner at Mercer Health & Benefits who studies and evaluates benefits among large employers, says that companies are providing more paid absence options for employees by allowing them to use sick time for family members or use vacation time and sick time interchangeably through a paid time off (PTO) plan.

Read More: Back-to-Office Pressure Is Creating a Crisis for Long COVID Patients

For example, according to a 2018 Mercer survey of employers, 18% of respondents said that sick leave must only be used for employees’ own illness. In 2021, that number was 12%, suggesting that companies are allowing wiggle room for workers who have to care for sick family members. That is stemming from HR departments and also externally from pandemic-era laws that mandate such allowances, Fuerstenberg says.

Similarly, in the 2018 survey, 61% of employers offered a PTO plan, rather than separately designated sick time and vacation time. In 2021, that number bumped up to 68%, but the range varies by industry, as the below chart shows.

“It’s still in that trend of flexibility,” Fuerstenberg says. “You can work things out between you and your manager—even among the hourly, non-exempt population—instead of having Big Brother looking over.”

Whether paid sick leave gains momentum in a meaningful way will also depend on the demands of the labor force. The pandemic drove employees to reevaluate their family time, physical health, and mental wellbeing. Even if their local laws don’t require paid sick leave, many workers will seek out the best work options for their lifestyle, and perhaps favor employers that offer generous benefits.

Alex Alonso, chief knowledge officer at the Society for Human Resource Management, believes that worker expectations—perhaps even more than labor laws—will determine the direction of paid leave going forward. Even before the pandemic, he says, paid leave laws expanded within a given industry when employers had to compete with one another for talent. The pandemic has only increased that pressure.

“Employees have been mindful that their employer is the steward of wellness programs in [their] life,” Alonso says. “Leave and paid leave is part of wellness. And today, talent has the upper hand.”

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6 Groups Making Mental Health Care More Accessible to BIPOC

6 Groups Making Mental Health Care More Accessible to BIPOC
6 Groups Making Mental Health Care More Accessible to BIPOC

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The COVID-19 pandemic worsened mental health across the board in the U.S., but people of color—who disproportionately suffered the worst effects of COVID-19 and have historically lacked adequate access to mental health care—were hit especially hard. One 2022 study found that Black, Hispanic, and Asian adults in the U.S. “exhibited much worse mental health during the pandemic compared to before the pandemic,” while white adults experienced a less stark decline.

Yet white Americans are still far more likely to receive professional mental-health care. Many obstacles keep people of color from receiving this sort of help, including financial and insurance limitations, a persistent stigma of seeking help for these issues in many communities of color, and barriers to finding a therapist with a similar cultural background.

Here are some organizations working to bridge that gap.

National Queer and Trans Therapists of Color Network

The National Queer and Trans Therapists of Color Network is a national organization that provides a directory of hundreds of queer and trans therapists of color. The organization, which was founded by therapist Erica Woodland in 2016, hopes to make it easier for queer and trans people of color to find mental-health practitioners. The organization also runs the Mental Health Fund for Queer and Trans Black, Indigenous and People of Color, launched in 2017, which has raised nearly $50,000 that has been distributed to “primarily Black, trans, and non binary folks” for their therapy needs, Woodland says. Applicants for the fund can request up to $100 per session for up to six sessions with a therapist.

Asian Mental Health Project

Carrie Zhang created the Asian Mental Health Project in 2017 after she noticed a lack of resources dedicated to Asian mental health. The organization educates and empowers pan-Asian communities to seek mental-health services by hosting mostly virtual wellness events, weekly check-ins that function as support groups, and workshops with speakers. The group also started fundraising for a mental-health fund through which the organization hopes to provide 25 people facing financial hardship with a $500 stipend to dedicate to mental health or wellness services.

Read More: How 988 Will Transform America’s Approach to Mental Health

“We anticipate people either using that money to seek a therapist or to take care of their therapy co-pays, but we also recognize that when it comes to mental health and wellness, it’s more than just therapy,” says Jennifer Tarm, director of partnerships at the organization. Acupuncture and other holistic modes of healing can also qualify.

HealHaus Therapy Fund

The HealHaus Therapy Fund, started by Brooklyn-based wellness center HealHaus, was created in 2021 to bring individual talk therapy to Black, Indigenous, and people of color (BIPOC); so far, 50 people have benefited from the fund. The fund’s ultimate goal is to offer eight weeks of free therapy to 100 people. “Therapy can be expensive and is considered a luxury for most,” says Darian Hall, co-founder of HealHaus. “Many insurance companies don’t cover therapy services, so this was a way for us to introduce therapy to those that may have never done it.”

Loveland Foundation’s Therapy Fund

The Loveland Foundation’s Therapy Fund was created in 2018 with a focus on Black girls, women, and nonbinary people who are seeking therapy. The fund covers up to 12 sessions for its recipients, and since it began it has already provided 72,000 hours of therapy. The Loveland Foundation also runs free support groups, which provide tools for navigating the challenges associated with mental illness in communities of color. “We’re working to provide equitable access to therapy and destigmatize the topic of mental health within our community,” says Hannah Tall, director of programs at the Loveland Foundation.

Therapy for Black Girls

Psychologist Joy Harden Bradford started Therapy for Black Girls as a mental-health blog in 2014, and by 2017, it had evolved to include a popular podcast and a therapist directory of predominantly Black female therapists. Today, more than 5,000 therapists are on the list. “There’s still a ton of stigma related to mental health in the Black community,” says Harden Bradford. “When people are considering therapy, one of the things that often makes them more comfortable is getting an appointment with a therapist who looks like them.”

Therapy for Latinx

Therapy for Latinx, which launched in 2018, provides a directory of about 500 therapists who specialize in issues relevant to the Latinx community. Founder Brandie Carlos came up with the idea after having trouble finding a therapist to help her cope with a friend’s suicide. While she found other directories for people of color, she didn’t come across anything specifically for the Latinx community—so she created one herself. “If I was having a hard time finding a therapist,” Carlos says, “I knew other people in my community were as well.”

If you or someone you know may be experiencing a mental-health crisis or contemplating suicide, call or text 988. In emergencies, call 911, or seek care from a local hospital or mental-health provider.

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Weight Lifting May Help You Live Longer, Study Says

Weight Lifting May Help You Live Longer, Study Says
Weight Lifting May Help You Live Longer, Study Says

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Lifting weights can build strength, add muscle, and put you in a good mood. Now, a new study finds that the practice may have an even bigger benefit: a longer life.

An observational study of nearly 100,000 people over about ten years, published Sept. 27 in the British Journal of Sports Medicine, found that people who reported lifting weights once or twice a week—without doing any other exercise—had a 9% lower risk of dying from any cause except for cancer. People who paired 1-2 days of weekly weight lifting with aerobic exercise fared even better; their risk of dying was 41% lower than those who did not exercise.

Jessica Gorzelitz, an assistant professor of health promotion at the University of Iowa and co-author of the study, says that the findings fit with the federal activity guidelines, which recommend that adults do at least 150 minutes of aerobic exercise per week, plus muscle-strengthening exercises two or more days a week. “If you want the biggest bang for your buck, the lowest risks were observed in those groups that were doing both aerobic exercise and weightlifting,” says Gorzelitz.

Read More: Can Exercise Prevent Depression? Here’s What the Science Says

While other studies have found that muscle-strengthening exercises improve health, Gorzelitz—who’s a power-lifter—says she couldn’t find any research on weight lifting and mortality, which is why she decided to study that question. The results are especially important for women, she says, because they seemed to get an even bigger benefit from weight lifting than men in the study. When Gorzelitz worked as a personal trainer, women often told her they feared that strength exercises would make them “too bulky”—a common misconception about weight lifting, Gorzelitz says. “Beyond our study, we see that it’s linked with better muscle mass, healthier muscle…and stronger bones,“ she says. “It’s really important to not just live long, but to live well.”

The study has several limitations. Researchers weren’t able to analyze the intensity and other details about the weight lifting workouts. People in the study also tended to be older than the general population, with an average age of 71, which means that the results might not generalize to younger adults.

It also raises further questions to explore. Even though the study did not find a link between weight lifting and a reduction in deaths caused by cancer, it could require longer term follow-up studies, says Alpa Patel, a senior vice president at the American Cancer Society. For instance, “we know from various other studies that strength training is beneficial for survival after a cancer diagnosis,” she says. Another intriguing finding was that people who did aerobic exercise and lifted weights three to seven times a week—which exceeds the federal guidelines—had an even lower risk of death, although Gorzelitz noted that this is a single study’s finding, and the guidelines come from the totality of evidence. So far, it’s unclear whether the benefits have an upper limit.

Other research provides plausible reasons why weight lifting could lower the risk of death. The exercise improves body composition, trims fat, and builds muscle, which research has linked to a lower risk of death from any cause, especially cardiovascular deaths.

Despite the clear benefits, however, less than a quarter of Americans meet the U.S. physical activity guidelines. “People don’t have to run out and start training for bodybuilding,” Gorzelitz says. “Doing something is better than nothing.” Start slow and look for help online or from a personal trainer, she says. “It’s okay to start with small steps for improving your health.”

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Mental health company for seniors launches with $32M seed round

Mental health company for seniors launches with M seed round
Mental health company for seniors launches with M seed round

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Rippl, a company focused on providing mental health solutions to seniors with dementia and other cognitive conditions, launched with a $32 million seed round led by ARCH Venture Partners and General Catalyst.

GV, F-Prime Capital and Mass General Brigham Ventures also participated. 

WHAT THEY DO

The company, led by Starbucks veteran Kris Engskov, said it will launch a care model offered by health plans that will provide 24/7 access to clinicians via the phone, online or in seniors’ homes. 

“One of the most obvious yet unaddressed areas of healthcare is how we treat seniors with cognitive impairments in their homes,” Robert Nelsen, Rippl cofounder and board chair, and managing director of ARCH Venture Partners, said in a statement. “We saw an opportunity to make a huge impact. We’ve pulled together a diverse team of people who come from a range of backgrounds. What connects them is they are all caregivers. We have a shared drive to redefine what a healthcare company looks like, and that’s by putting clinicians at the center of every decision we make.”

WHAT IT’S FOR

Rippl plans to use the seed funding to hire and train clinicians, build the technology, and open a Washington state-based clinical support center to launch pilot networks in two regions, starting in Seattle.

MARKET SNAPSHOT

According to the Census Bureau, the senior population has grown significantly over the past 10 years, driven by the aging of the large Baby Boomer generation. As society experiences the demographic shift, referred to as the “gray tsunami,” there will be an increasing need for caregivers and health clinics to meet the demands of the aging group. 

Several companies are focused on creating solutions for the aging population. Homethrive, a platform that aims to support people who are caring for older relatives or loved ones with disabilities, recently raised $20 million. DUOS, which announced a $15 million Series A in April, helps older adults set up rides, arrange for food deliveries, help find housing and manage medical care.

Another senior assistance startup, Papa, announced a $150 million Series D round in November 2021.

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The First U.S. Data Show the Monkeypox Vaccine Is Effective

The First U.S. Data Show the Monkeypox Vaccine Is Effective
The First U.S. Data Show the Monkeypox Vaccine Is Effective

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We now have the first real-world data showing how well the monkeypox vaccine is working in the current U.S. outbreak. On Sept. 28, the U.S. Centers for Disease Control and Prevention (CDC) posted preliminary data from 32 jurisdictions in the U.S. that reported monkeypox case rates and rates of vaccination with Jynneos, the vaccine currently being used against monkeypox. By comparing the two, researchers were able to preliminarily quantify how effective the vaccine is, CDC director Dr. Rochelle Walensky said during a briefing.

People who had received the first dose of the two-dose Jynneos vaccine were 14 times less likely to get infected with monkeypox at least two weeks later than those who were unvaccinated.

Jynneos was approved in the U.S. to control smallpox and monkeypox in 2019. The monkeypox approval was based on data from animals studies, since cases of the disease were not widespread in the U.S. at the time. The animal data provided a proxy for how well the shot would work in people, which now seems to be supported by real-world data.

Walensky said the results “provide a level of cautious optimism that the vaccine is working as intended.” She stressed that the findings involved people who were two weeks out from their first dose of the two-dose vaccine, and urged people to receive the second dose as recommended—28 days after the first—in order to benefit from the strongest, most durable protection against infection. Still, the results suggesting protection against infection after the first shot are encouraging.

The findings prompted the CDC to expand the group of people who are eligible for Jynneos to include those who might be at high risk of exposure to the virus; they can now use the vaccine as a way to protect themselves proactively. These include partners of people who might be at high risk of exposure, as well as commercial sex workers. Known as pre-exposure prophylaxis, this practice represents a shift in the U.S. government’s strategy in controlling the outbreak. Expanding eligibility will be “critical to making sure we keep getting vaccines into arms for both the first and second doses,” said Dr. Demetre Daskalakis, White House monkeypox response deputy coordinator, during the briefing. “It means more people at present or future risk of monkeypox now qualify for the vaccine.”

While cases of monkeypox continue to decline—the U.S. currently has about 200 a week, compared to a peak of about 1,000 weekly cases in August—that’s largely due to increased education about the disease and risk factors, as well as the countrywide vaccination program, officials said. “This is the first view of how well the vaccine is working after just one dose,” Walensky said. “It’s terrific news, but what we know from lab data is that the second dose is really important and may provide the durable protection we need to control the outbreak.”

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Grocery delivery company Instacart launches health division

Grocery delivery company Instacart launches health division
Grocery delivery company Instacart launches health division

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Grocery delivery service Instacart is launching a new health division as the company prepares for its upcoming initial public offering

Instacart Health will include new products focused on providing nutritious foods, strategic partnerships with organizations like Partnership for a Healthier America and food-policy advocacy, like expanding online access to EBT SNAP and TANF assistance programs.

One of Instacart’s new offerings is Fresh Funds, a program that gives nonprofits, insurers and employers a way to provide money for nutritious foods. It will also launch Care Carts, a service that allows providers and caregivers to place grocery orders on a patient or family member’s behalf.

Instacart said companies like hospital-at-home company Medically Home and digital nutrition startup Season Health are already using this tool. Health Tags, another new offering, will add new labels to foods in its app, like low-salt, low-sugar, keto and gluten-free.

On the partnerships front, Instacart is working with Hearst Magazines to expand its recipe library and is collaborating with weight-loss company Found to add its nutrition guidance and recipes to the app. It will also work with Partnership for a Healthier America to raise funds to provide fruits and vegetables to food-insecure families.

“Our nation’s hunger and health problems are complex and require cross-sector collaboration. At Instacart, we’re building the technologies that can help many organizations – from healthcare providers, insurers, nonprofits, employers and health experts – give more people access to fresh, nutritious foods with dignity, speed and convenience,” Fidji Simo, CEO of Instacart, said in a statement.

THE LARGER TREND

Instacart launched a decade ago in the San Francisco Bay Area, and has since expanded its grocery delivery services to other cities in the U.S. and Canada.

In May, it filed a draft registration statement with the Securities and Exchange Commission to prepare for an IPO. The Information recently reported that Instacart has been letting go of workers, slowing the pace of hiring and cutting expenses as it nears closer to its debut on the public markets. 

The company grew during the COVID-19 pandemic as consumers opted to stay home to avoid infection, but in March Instacart cut its valuation to about $24 billion from $39 billion.

Other delivery and ride-sharing tech companies like Uber and Lyft have also expanded into the healthcare space. Digital health startups focused on nutrition include Culina Health, which offers virtual appointments with dieticians and recently raised $4.75 million, and Season Health, one of Instacart’s Care Carts partners.

It allows patients to work out meal plans based on their health needs and have food delivered to their homes. In April, Season announced it had scooped up $34 million in a Series A funding.

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Strongman Evan Singleton’s 2022 Season is Over After Successful Bicep Surgery

Strongman Evan Singleton’s 2022 Season is Over After Successful Bicep Surgery
Strongman Evan Singleton’s 2022 Season is Over After Successful Bicep Surgery

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On Sept. 24, 2022, in a video on his Instagram, strongman Evan Singleton announced that he recently tore his right distal biceps tendon during a training session. He withdrew from the upcoming 2022 Giants Live World Tour Finals on Oct. 8, 2022, in Glasgow, Scotland, and the 2022 Rogue Invitational on Oct. 28-30, 2022, in Austin, TX. (Note: At the time of this writing, a replacement for Singleton in both contests hasn’t been revealed.)

In a Sept. 28, 2022, Instagram update, Singleton announced that he underwent successful surgery to reattach his biceps tendon. The athlete did not offer a concrete timetable for a full recovery from his injury but alluded to plans to try and compete in the 2023 World’s Strongest Man (WSM). 

[Related: The Best Landmine Workouts for More Muscle and Better Conditioning]

Before his surgery, in one of his apparent last heavy lifting sessions for a while, Singleton shared a Sept. 25 Instagram clip of himself powering through some heavy box squats. The athlete completed a 340-kilogram (751-pound) set for three reps.

“The last time I’ll be lifting heavy for a while, so might as well make it good,” Singleton wrote of his box squat workout. “Definitely ran on pure anger and hate today. I didn’t really realize how upset I was until the weights got heavier and heavier. The more weight there was, it was almost like it was just pulling the emotion to the surface. I’m going to be getting real friendly with squats again after surgery.”

 

Singleton would subsequently upload a Sept. 28, 2022, video to his YouTube channel focusing on his deadlift. Because he couldn’t apply any pressure to his right arm, the strongman wore a protective body strap. He would capture a 385.6-kilogram (850-pound) pull for his best one-rep. After finishing deadlifting, Singleton trained his left arm with lateral raises, dumbbell biceps curls, and cable curls.

To outline his future plans in the YouTube video, Singleton maintained that the 2023 WSM will be his “first stop.” Following that, he will intend to get back onto the Giants Live circuit and the 2023 Rogue Invitational. In 2021, he notably won the 2021 Giants Live World Open and the 2021 Arnold Strongman Classic UK — the inaugural edition of the contest.

Depending on Singleton’s recovery and training, he may well return to that high standard of performance come next year. 

Featured image: @evan_trex_strongman on Instagram

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10 Readers Share their Happy Moments

10 Readers Share their Happy Moments
10 Readers Share their Happy Moments

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Life isn’t easy, so sometimes we like to highlight the things that make it sweet. We asked readers on Instagram to share photos of good times, and here are 10 that made us weepy…

Above: “Here’s a selfie with my niece, Juniper, poolside at my parents’ house. The chaos of my big family, with all my siblings and their kids, is my happy place!” — Justine

“The other evening, I was very happily putting the finishing touches on my first solo exhibition in Brooklyn and feeling so proud of the work.” — Allie

“My sweet rescue puppy was diagnosed with kidney disease in March, shortening her life span. I was absolutely crushed and wanted to make the rest of her life the happiest it could be. One month later, we walked into the dog park, and my pup ran directly to a pit bull… and his VERY cute owner. We learned we were both single, 32, and Greek, and we began dating. I really believe my pup brought this man to me.” — Laura

“Seeing Stevie Nicks in concert! I am a huge fan, and it was a dream come true.” — Sally

“My boyfriend and I were road-tripping across the country. We had been talking about getting married for a while, and we decided to just go for it! Our next stop was Minneapolis, so we made a couple phone calls, talked to the world’s kindest judge clerk, and had an impromptu ceremony.” — Brinda

“I met my best friend when we were eight, and as adults we’ve always lived apart. We have a tradition to spend NYE together, and here I’d flown a thousand miles to meet her in Riding Mountain National Park, where she lived. Temperatures there are so cold (-40) that when you throw water in the air it immediately freezes. We decided to try it out, running out of the warm car for 60 seconds while our husbands captured the moment. Simple joys with our most loved ones, that’s all that matters.” — Amrita

“After years of trying and multiple miscarriages, I found out I was pregnant. But I wasn’t emotionally able to feel excited. The moment they handed my daughter to me, however, all the fear lifted off of my chest and was replaced with love, gratitude, and the weight of her perfect, tiny body.” — Natalie

“I swam my best-ever distance (5km in 2h) at my local pool. I am so proud of myself! All my life, people told me that I need to lose weight to be fit. I believed them for quite a while. Then I started doing my own thing about a year ago and was amazed what my body could do despite being overweight. Today just marks the beginning of an even more body positive journey for me! Don’t let anyone tell you what you can’t do.” — Kristin

“My son and I take a daily selfie at school drop-off. On his first day of first grade, I asked if he wanted me to walk him in, but he said he knew where to go. I was feeling sad that he didn’t need my help when he said, ‘Wow, I’m in first grade now. I’m so proud of me. Right, Mom?’ Happiness comes in many forms but most often it is from this special person I have the opportunity to raise and cherish.” — Katherine

“This summer, I flew out to see my brother and sister-in-law in Indiana, and it was the happiest reunion. They’d brought a freshly baked loaf of sourdough to the airport, so we pulled into a parking lot for a spontaneous picnic on the back of the car.” — Maddie

What’s been one of your recent good moments? Please share below…

P.S. Readers share their solo travel photos and readers reveal what they love about their looks. Also, happiness vs. wholeness.

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Vision benefits company XP Health raises $17.1M and more digital health fundings

Vision benefits company XP Health raises $17.1M and more digital health fundings
Vision benefits company XP Health raises .1M and more digital health fundings

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XP Health, a company developing a digital-first vision benefits platform, raised $17.1 million in a Series A funding round led by HC9 Ventures, Valor Capital Group and ManchesterStory. 

Additional investors include Core Innovation Capital, GSR Ventures, Canvas Ventures, Plug and Play, CameronVC, Ken Goulet, Kevin Hill, Jeff Epstein and Brett Rochkind. This recent funding round followed a $5.5 million raise in 2021.

“This round of funding enables us to strengthen the platform’s functionality and provide a stellar consumer experience in the most affordable way to employers, insurance carriers and employees,” Antonio Moraes, cofounder and CEO of XP Health, said in a statement.

“We have a game-changing offering for how people access and experience employee benefits – with an ultimate goal to positively impact hundreds of millions of lives through high-quality, accessible and affordable health benefits.”


Lung-health company Optellum announced closing a $14 million Series A funding round led by U.K. venture capital firm Mercia with participation from U.S. firms Intuitive Ventures and Black Opal.

Its Virtual Nodule Clinic software is used to track, assess and characterize nodules in the lungs. The company attained FDA clearance in the U.S., CE-MDR in the European Union, and UKCA in the United Kingdom for the platform. A CE mark certificate (CE-MDR) is needed to commercialize medical devices in the EU. The U.K. Conformity Assessed marking indicates a product conforms with applicable requirements to be sold in Great Britain.

“[Virtual Nodule Clinic] can help physicians identify and track at-risk patients, and optimally diagnose the signs of lung cancer early — so treatment can be started sooner for patients with tumors, and to minimize invasive procedures such as biopsies on benign lesions,” the company said in a press release. 


The company behind the Cionic Neural Sleeve received $12.5 million in a Series A funding led by BlueRun Ventures, with participation from EPIC Ventures, LDV Capital, Caffeinated Capital and JobsOhio Growth Capital Fund. 

This round of funding follows Cionic Neural Sleeve’s FDA clearance in early 2022. The leg-worn device provides electrical stimulation so people with foot drop and muscle weakness can walk more easily. Cionic has so far received $23 million to build its platform focused on human mobility. 

The new round of funds will help the company expand manufacturing and delivery of its mobility technology, and accelerate research trials and commercialization of its products for new indications. 

“Forward-looking investors realize that we need to take action today, and we are proud to be backed by a group of investors who recognize the need for better solutions and have joined us in our mission to redefine human mobility,” Cionic founder and CEO Jeremiah Robison said in a statement. 


Kaleidoscope, a cloud-based research platform that maps data usage by R&D teams, solidified a $6 million seed financing round.

It was co-led by Hummingbird Ventures and Dimension, with participation from SV Angel, Hawktail, Caffeinated Capital and individual investors.

The funding will help the company further develop the platform’s product and expand the company’s team, especially with software engineers. 

“The way people work in research is changing. Kaleidoscope bridges the gap between teams on a platform that integrates with other software tools. The funding will enable us to deliver the best product and user experience to make research more collaborative, reproducible and scalable,” Bogdan Knezevic, CEO and cofounder of Kaleidoscope, said in a statement.


Arcascope, a health technology company focusing on circadian rhythm disruption, announced it closed a $2.85 million seed round.

The round was led by Supermoon Capital, with participation from New Dominion Angels, Inflect Health, Inception Health, the Accelerate Blue Fund, the Monroe Brown Seed Fund, AIoT Health, HealthX Ventures and other angel investors. 

The company is launching a circadian rhythm management platform, currently accessible via the smartphone app, Shift, to address the sleep needs of shift workers. 


Surge, a company developing machine learning technology to decode a patient’s blood sample to forecast the risk of postoperative complications, announces a $2.6 million round co-led by HCVC and Boutique Venture Partners, with participation by Nicolas Godin. 

The company also obtained the exclusive license to the patented postoperative complication prediction technology from Stanford University, which includes 10+ years of research on surgical risk prediction. Surge also signed a research agreement with Stanford intending to develop biotech innovations. 

This new round of funding will support the company in developing its team further and conducting clinical studies with more hospitals. 

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